Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68

Figure 7

Immunohistochemical staining of a lymph node with PC-3 metastases. At day 57 after PC-3 cells implantation, tumor-bearing mice were injected with 5 × 10⁶ pfu of GLV-1h68. At day 11 after virus injection, whole lumbar lymph node cross-sections were analyzed by bright-field imaging (a) or by fluorescence microscopy techniques. (b) Phalloidin-TRITC (red) and (c) anti-VACV antibody (green), and (d) (overlay). Scale bars = 1 mm. *indicates the dead tumor tissue destructed by GLV-1h68.

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