Regression of Human Prostate Tumors and Metastases in Nude Mice following Treatment with the Recombinant Oncolytic Vaccinia Virus GLV-1h68
Table 2
Mouse immune-related protein antigen profiling in PC-3-derived tumors of male or female nude mice with or without GLV-1h68 treatment at the day 42 after virus infection (). Folds of enhancement (a) or suppression (b) of mouse protein expression after virus injection are shown. Each value was determined as the mean of triplicate determination.
(a) Upregulated protein expression levels (day 42 after virus infection).
Antigen names
GLV-1h68/untreated ratio (female)
GLV-1h68/untreated ratio (male)
Classification
Apo A1
2.83
2.78
Anti-inflammatory protein
GM-CSF
2.2
2.77
Granulocyte-macrophage colony-stimulating factor
IL-6
8.44
6.8
Proinflammatory cytokine
IL-11
3.81
3.63
Pleiotropic cytokine
IL-18
30
29.72
Proinflammatory cytokine
IP-10 (CXCL10)
33.91
8.18
Interferon-gamma-induced protein
MCP-1 (CCL2)
11.8
7.05
Proinflammatory cytokine
MCP-3 (CCL7)
6.09
3.23
Proinflammatory cytokine
MCP-5 (CCL12)
30.24
10.64
Proinflammatory cytokine
M-CSF (KC/GROα)
2.18
2.48
Proinflammatory cytokine
MDC (CCL22)
4.5
3.23
Proinflammatory chemokine
MIP-1beta
9.09
3.31
Proinflammatory cytokine
MIP-2 (CXCL2)
2.9
3.33
Proinflammatory chemokine
RANTES (CCL5)
7.1
4.58
Proinflammatory chemokine
TIMP-1
2.6
2.43
Tissue inhibitor of metalloproteinase type-1
TNF-alpha
2.56
2.27
Proinflammatory cytokine
(b) Downregulated protein expression level (day 42 after virus infection).
