SLE is known to be associated with increased expression of interferon-inducible genes and these genes have a strong association of H4ac and gene expression. We noted another cluster had a similarly strong association of H4ac and gene expression. The chemokine cluster was identified as having significantly decreased expression and H4ac in SLE monocytes. (a) The heatmap demonstrating the association of gene expression and H4ac. (b) The statistical relationship between the groups.
