Elementary Mode Analysis for the Rational Design of Efficient Succinate Conversion from Glycerol by Escherichia coli
Figure 7
Sensitivity of succinate yield to the relative fluxes at the (a) PEP node and (b) AcCoA node under aerobic conditions. The PEP node involves the catabolic reactions of R40 and R17 which are catalyzed by PEP carboxylase and pyruvate kinase, respectively. The AcCoA node involves the catabolic reactions of R22, R50, R44, and R53 which are catalyzed by citrate synthase, aldehyde dehydrogenase, malate synthase, and phosphate acetyltransferase, respectively.
