A Styrene-alt-Maleic Acid Copolymer Is an Effective Inhibitor of R5 and X4 Human Immunodeficiency Virus Type 1 Infection
Figure 2
alt-PSMA inhibits infection by HIV-1 strains BaL and IIIB. P4-R5 MAGI cells were incubated for 2 h with HIV-1 strains (a) BaL or (B) IIIB in the absence or presence of alt-PSMA or DS (as described in Section 2). For the preincubation portion of the experiment, compound and virus were first incubated for 10 min prior to dilution and addition to cells. Infectivity remaining was expressed relative to mock-treated, HIV-1-infected cells and graphed against the compound concentration achieved during the 2-h incubation. Each concentration was examined in triplicate in two independent assays.
