BioMed Research International

Research Article

Intranasal Immunization with Chitosan/pCAGGS-flaA Nanoparticles Inhibits Campylobacter jejuni in a White Leghorn Model

Table 2

Ratio of CD4+/CD8+ T cells in spleen and cecal tonsil of immunized chickens.
Group R a t i o a of CD4+/CD8+ T cells in spleen R a t i o a of CD4+/CD8+ T cells in cecal tonsil
Second immunizationThird immunizationSecond immunizationThird immunization
CS-pCAGGS-flaA 1 . 3 4 ± 0 . 5 3 b 1 . 5 4 ± 0 . 2 3 b 0 . 9 8 ± 0 . 1 7 1 . 9 4 ± 0 . 2 1 b
CS-pCAGGS 0 . 6 3 ± 0 . 2 2 0 . 9 4 ± 0 . 2 2 0 . 9 2 ± 0 . 2 6 1 . 2 9 ± 0 . 1 8
PBS 0 . 6 2 ± 0 . 0 5 1 . 0 0 ± 0 . 0 8 1 . 1 7 ± 0 . 3 0 1 . 2 7 ± 0 . 3 0
a Values are means ± standard deviations (four samples per group) for ratio of CD4+/CD8+ T cells treated with CS-pCAGGS-flaA and CS-pCAGGS or PBS.
b Significantly different ( 𝑃 < . 0 5 ) among vaccine groups as calculated by Student’s 𝑡 -test.