BioMed Research International

Research Article

Absorption, Distribution, Excretion, and Pharmacokinetics of -Pyronaridine Tetraphosphate in Male and Female Sprague-Dawley Rats

Table 1

Plasma and blood pharmacokinetic parameters in male and female Sprague-Dawley rats after administration of a single oral dose of 10 mg/kg of 14C-PNDP (mean±SD, 𝑛 = 6 ).
𝐶 m a x 𝑇 m a x 𝑡 1 / 2 A U C 2 4 0 h r A U C i n f
(ng/mL)(hr)(hr)( 𝜇 g ⋅ hr/mL)( 𝜇 g ⋅ hr/mL)
Male SD-ratPlasma 2 0 7 . 2 ± 3 1 . 9 7 . 3 ± 1 . 6 1 4 8 . 5 ± 3 9 . 1 1 4 . 1 ± 1 . 5 2 1 . 4 ± 4 . 0
Whole blood 2 2 2 . 8 ± 2 0 . 9 1 0 . 7 ± 6 . 5 1 3 8 . 1 ± 5 2 . 7 2 5 . 0 ± 1 . 8 3 5 . 6 ± 5 . 4
Female SD-ratPlasma 1 8 9 . 2 ± 4 8 . 4 8 . 0 ± 0 . 0 1 5 7 . 5 ± 3 0 . 3 1 4 . 7 ± 1 . 1 2 3 . 1 ± 2 . 3
Whole blood 2 2 0 . 6 ± 2 1 . 0 8 . 0 ± 0 . 0 2 1 1 . ± 5 1 . 7 2 3 . 1 ± 2 . 8 3 8 . 8 ± 3 . 7