Mitoxantrone Loaded Superparamagnetic Nanoparticles for Drug Targeting: A Versatile and Sensitive Method for Quantification of Drug Enrichment in Rabbit Tissues Using HPLC-UV

Table 5

Amount of MTO in different tissues after intravenous application of ferrofluid-bound MTO. New Zealand White rabbits (𝑛=5) were treated with 10% of the systemic necessary dose (10 mg/𝑚² body surface).

Tissue	Detected MTO [ng] per g tissue^(1)
Lung	30±17
Liver	89±22
Kidneys	537±94
Muscle tissue	1.4±0.7^(2)

⁽¹⁾deviation calculated as sem (standard error of the mean)
⁽²⁾concentration below the quantitation limit.