Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model

<table><i>New Bone Volume Quantified from the MicroCT Analysis</i> (<svg height="13.775" id="M8" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 30.5375 13.775" width="30.5375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.775)">
<g transform="translate(72,-60.98)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">m</tspan>
<tspan style="font-size: 12.50px; " x="9.727334" y="0">m</tspan>
</text>
<text transform="matrix(1,0,0,-1,-52.5,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">3</tspan>
</text>
</g>
</g>
</svg>). The volume of new bone (<svg height="13.775" id="M9" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 30.5375 13.775" width="30.5375" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,13.775)">
<g transform="translate(72,-60.98)">
<text transform="matrix(1,0,0,-1,-71.95,61.03)">
<tspan style="font-size: 12.50px; " x="0" y="0">m</tspan>
<tspan style="font-size: 12.50px; " x="9.727334" y="0">m</tspan>
</text>
<text transform="matrix(1,0,0,-1,-52.5,66.03)">
<tspan style="font-size: 8.75px; " x="0" y="0">3</tspan>
</text>
</g>
</g>
</svg>) formed in each treatment group (gray bars) was compared to the volume of new bone formed in the contralateral, blank-treated femurs (black bars) for that group using Students <svg height="9.125" id="M10" style="vertical-align:-0.11285pt" version="1.1" viewbox="0 0 5.0124998 9.125" width="5.0124998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,9.125)">
<g transform="translate(72,-64.7)">
<text transform="matrix(1,0,0,-1,-71.95,64.86)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑡</tspan>
</text>
</g>
</g>
</svg>-tests. Significant <svg height="10.325" id="M11" style="vertical-align:-0.0pt" version="1.1" viewbox="0 0 11.75 10.325" width="11.75" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.325)">
<g transform="translate(72,-63.74)">
<text transform="matrix(1,0,0,-1,-71.95,63.79)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
</text>
</g>
</g>
</svg>-values are shown (LD: low-dose; HD: high-dose).</table>

BioMed Research International

fig3

Figure 3

Figure 3: Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model 