Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model
Histological Sections of Femur Defects. Following micro CT evaluation, specimens were plastic embedded, sectioned through the defect, and stained for mineralized tissue (red) and cartilage (deep blue). Shown are representative cross-sections from (a) an empty defect and defects treated with (b) high-dose alendronate, (c) high-dose lovastatin, and (d) high-dose omeprazole. ROI-1 is shown and included the defect site and marrow space (a)-left. ROI-2 is shown and bone outside of ROI-2 was considered peripheral bone formation (a)-right. Corresponding blank-treated defects from each treatment group are shown in the right column. Mineralized tissue was evident in all defect sites but little or no cartilage was observed.
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