Osteogenic Activity of Locally Applied Small Molecule Drugs in a Rat Femur Defect Model

Table 2

Effects of Drug Therapy on New Bone Volume.

Treatment	Implant; weight (mg)	Percent; drug (w/w)	Approx.; site dose (ug)	Group size	Bone volume (mm^3; mean ± S.D.)		t-test
					Drug	Blank	𝑃 value
Empty Defect	0	0	0	5	2.312 ± 0.810	2.271 ± 0.564	.929
Low-Dose Alendronate	13.6 ± 0.8	0.05	6.8	4	4.749 ± 1.343	2.487 ± 0.952	.033
High-Dose Alendronate	11.4 ± 0.6	0.23	26.2	5	4.893 ± 0.385	2.897 ± 0.125	< .001
Low-Dose Lovastatin	16.1 ± 0.5	0.05	8.0	6	2.833 ± 1.370	2.199 ± 0.409	.303
High-Dose Lovastatin	13.0 ± 0.7	0.5	65	6	2.746 ± 1.410	2.853 ± 0.916	.880
Low-Dose Omeprazole	14.6 ± 0.5	0.1	14.6	6	2.936 ± 0.695	3.722 ± 1.145	.181
High-Dose Omeprazole	13.7 ± 0.6	1	137	6	3.029 ± 0.634	2.833 ± 0.783	.645