Reduction of Ischemic and Oxidative Damage to the Hypothalamus by Hyperbaric Oxygen in Heatstroke Mice

Figure 3

Effects of heat exposure (42.4^∘C for 1 hour) on hypothalamic levels of tumor necrosis factor-𝛼 (TNF-𝛼), interleukin-1𝛽, interleukin-10 and myeloperoxidase (MPO) of normothermic mice received normobaric air (A), normothermic mice received hyperbaric oxygen (B), heatstroke mice received normobaric air (C), and heatstroke mice received hyperbaric oxygen (D). ^∗𝑃<.01 compared with corresponding control values in group (A). ^†𝑃<.01 compared with corresponding control values in group (C). Bars are mean ± SE of eight mice per group. Samples were obtained at 4 hours after the termination of 1-hour heat exposure or the equivalent time for the normothermic controls.