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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 612482, 7 pages
Review Article

Roles of Titin in the Structure and Elasticity of the Sarcomere

Institute for Molecular and Cellular Biology and Astbury Centre for Structural Molecular Biology, University of Leeds, Leeds LS2 9JT, UK

Received 16 February 2010; Accepted 13 May 2010

Academic Editor: Aikaterini Kontrogianni-Konstantopoulos

Copyright © 2010 Larissa Tskhovrebova and John Trinick. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The giant protein titin is thought to play major roles in the assembly and function of muscle sarcomeres. Structural details, such as widths of Z- and M-lines and periodicities in the thick filaments, correlate with the substructure in the respective regions of the titin molecule. Sarcomere rest length, its operating range of lengths, and passive elastic properties are also directly controlled by the properties of titin. Here we review some recent titin data and discuss its implications for sarcomere architecture and elasticity.