Application of “omics” to Prion Biomarker Discovery

Table 1

Genes with differential abundances in prion disease and other neurodegenerative disorders.

Gene	Description	Reference for Prion Disease	Other Neurodegenerative Disorder∗
ABCA1	ATP-binding cassette, subfamily A (ABC1), member 1	[20, 22, 23]	AD
APLP1	Amyloid beta (A4) precursor-like protein 1	[20]	AD
APOD	Apolipoprotein D	[20, 20, 23, 25, 28]	AD, NPC
APOE	Apolipoprotein E	[20, 22, 25]	AD, PD and MTS
B2M	Beta-2-microglobulin	[20, 22, 25, 29]	AD, Tay-Sachs, Sandhoff disease, and MTS
CD9	CD9 molecule	[20, 22, 23, 25]	SSPE, CMT
CLU	Clusterin	[20, 25, 30]	AD, PD
CST3	Cystatin C (amyloid angiopathy and cerebral hemorrhage)	[20, 25, 30]	AD, MTS
CTSB	Cathepsin B	[20, 22, 25]	AD, Seizures, Tay-Sachs, and Sandhoff disease
CTSS	Cathepsin S	[20, 22, 23, 25, 28]	AD
GFAP	Glial fibrillary acidic protein	[20, 22, 23, 25, 28]	Tay-Sachs, Sandhoff disease, MTS, and AD
SPARC	Secreted protein, acidic, cysteine-rich (osteonectin)	[20]	Tay-Sachs, Sandhoff disease, and MTS
SPP1	Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)	[20, 22]	PD

∗AD: Alzheimer's Disease; PD: Parkinson's Disease; NPC: Niemann-Pick type C; MTS: Mesial temporal sclerosis; SSPE: Subacute sclerosing panencephalitis, CMT: Charcot-Marie-Tooth disease.