| Gene | Description | Reference for Prion Disease | Other Neurodegenerative Disorder |
| ABCA1 | ATP-binding cassette, subfamily A (ABC1), member 1 | [20, 22, 23] | AD | APLP1 | Amyloid beta (A4) precursor-like protein 1 | [20] | AD | APOD | Apolipoprotein D | [20, 20, 23, 25, 28] | AD, NPC | APOE | Apolipoprotein E | [20, 22, 25] | AD, PD and MTS | B2M | Beta-2-microglobulin | [20, 22, 25, 29] | AD, Tay-Sachs, Sandhoff disease, and MTS | CD9 | CD9 molecule | [20, 22, 23, 25] | SSPE, CMT | CLU | Clusterin | [20, 25, 30] | AD, PD | CST3 | Cystatin C (amyloid angiopathy and cerebral hemorrhage) | [20, 25, 30] | AD, MTS | CTSB | Cathepsin B | [20, 22, 25] | AD, Seizures, Tay-Sachs, and Sandhoff disease | CTSS | Cathepsin S | [20, 22, 23, 25, 28] | AD | GFAP | Glial fibrillary acidic protein | [20, 22, 23, 25, 28] | Tay-Sachs, Sandhoff disease, MTS, and AD | SPARC | Secreted protein, acidic, cysteine-rich (osteonectin) | [20] | Tay-Sachs, Sandhoff disease, and MTS | SPP1 | Secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1) | [20, 22] | PD |
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