Ordered Assembly of the Adhesive and Electrochemical Connections within Newly Formed Intercalated Disks in Primary Cultures of Adult Rat Cardiomyocytes

Figure 1

Reassembly of cell-cell contacts in remodeling adult rat cardiac myocytes in culture. (a, b) On days 1–3 post plating, the cell rounds up, the IDs disassemble, and cadherins redistribute along the periphery of the cell (arrow in b). (c, d) Between days 5–7, new cell-cell contacts form and cadherin localizes to specific domains along the line of apposition (arrows). (e) By 14 days post plating, the cell-cell contacts have remodeled to form more localized and mature structures (arrow). Scale bars are 20 𝜇m.