Research Article
Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects
Table 2
MDR-P results (adjusted P values) for all 2-locus models of the inherited genotype and CTRD, Children’s Hospital of Philadelphia, 1997–2007.
| | BHMT | CBS | DHFR | MCP1 | MTHFR | MTHFR | MTR | MTRR | SHMT | TCN2 | | G742A | 844ins68 | 19-bp del | A251G | C677T | A1298C | A2756G | A66G | C1420T | C777G |
| BHMT G742A | | 0.75 | 0.27 | 0.69 | 0.43 | 0.18 | 0.50 | 0.68 | 0.92 | 0.57 | CBS 844ins68 | | | 0.40 | 0.38 | 0.59 | 0.09 | 0.48 | 0.92 | 0.45 | 0.63 | DHFR 19-bp del | | | | 0.92 | 0.60 | 0.72 | 0.82 | 0.28 | 0.26 | 0.86 | MCP1 A251G | | | | | 0.58 | 0.83 | 0.60 | 0.53 | 0.47 | 0.67 | MTHFR C677T | | | | | | N/A* | 0.30 | 0.60 | 0.43 | 0.10 | MTHFR A1298C | | | | | | | 0.13 | 0.23 | 0.13 | 0.32 | MTR A2756G | | | | | | | | 0.57 | 0.13 | 0.74 | MTRR A66G | | | | | | | | | 0.88 | 0.18 | SHMT C1420T | | | | | | | | | | 0.93 |
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his interaction was not assessed as the two MTHFR variants are in strong linkage disequilibrium.
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