Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects

Table 4

Maternal MTHFR and CBS 844ins68 genotype combinations, Children’s Hospital of Philadelphia, 1997–2007.

		CBS 844ins68
	II	IN	NN	P value
MTHFR genotypes
C677T
CC (%)	4 (2.5)	19 (11.8)	138 (85.7)
CT (%)	0	31 (16.0)	163 (84.0)
TT (%)	0	2 (3.6)	54 (96.4)	.01
A1298C
AA (%)	1 (0.5)	20 (10.2)	175 (89.3)
AC (%)	1 (0.5)	27 (14.9)	153 (84.5)
CC (%)	2 (6.1)	5 (15.2)	26 (78.9)	.02