Gene-Gene Interactions in the Folate Metabolic Pathway and the Risk of Conotruncal Heart Defects

Table 5

Relative risk of CTRD for maternal MTHFR C677T/CBS 844ins68 genotype combinations estimated by log-linear regression, Children’s Hospital of Philadelphia, 1997–2007.

	CBS 844ins68
	II/IN		NN
	RR	(95% CI)	RR	(95% CI)	P for interaction*
MTHFR C677T
CC	1		1
CT	1.26	(0.59, 2.69)	1.10	(0.79, 1.53)
TT	0.57	(0.10, 3.45)	1.85	(1.13, 3.02)	.02

^∗Based on the likelihood ratio test of no interaction.