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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 642804, 16 pages
http://dx.doi.org/10.1155/2010/642804
Review Article

Prospects for the Use of Artificial Chromosomes and Minichromosome-Like Episomes in Gene Therapy

1Departamento de Biología Molecular, Universidad Autónoma de Madrid, 28049 Madrid, Spain
2Centro de Biología Molecular “Severo Ochoa” (CSIC-UAM), C/Nicolás Cabrera 1, Universidad Autónoma de Madrid, 28049 Madrid, Spain
3U-748, Area de Neurogenética, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Spain

Received 19 February 2010; Revised 2 June 2010; Accepted 5 July 2010

Academic Editor: Rudi Beyaert

Copyright © 2010 Sara Pérez-Luz and Javier Díaz-Nido. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

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  • An Weuts, Thierry Voet, Jelle Verbeeck, Nathalie Lambrechts, Evelyne Wirix, Luc Schoonjans, Sophie Danloy, Peter Marynen, and Guy Froyen, “Telomere length homeostasis and telomere position effect on a linear human artificial chromosome are dictated by the genetic background,” Nucleic Acids Research, vol. 40, no. 22, pp. 11477–11489, 2012. View at Publisher · View at Google Scholar
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  • Cassandra J Strawser, Kimberly A Schadt, and David R Lynch, “Therapeutic approaches for the treatment of Friedreich’s ataxia,” Expert Review of Neurotherapeutics, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • S. Pérez-Luz, A. Gimenez-Cassina, I. Fernández-Frías, R. Wade-Martins, and J. Díaz-Nido, “Delivery of the 135kb human frataxin genomic DNA locus gives rise to different frataxin isoforms,” Genomics, 2015. View at Publisher · View at Google Scholar