Figure 8: Overview of biological functions of DIGE-identified proteins with an altered expression in dystrophic heart muscle. The pie chart summarizes the apparent functions of DIGE-identified proteins with a differential expression in normal versus dystrophin-deficient MDX heart muscle. A large proportion of these affected proteins belong to cardiac mitochondria including metabolic elements of oxidate phosphorylation, the citric acid cycle and fatty acid transportation, as well as proteins associated with the contractile apparatus, the cellular stress response, and the cytoskeletal network.