Myosin Binding Protein-C Slow: An Intricate Subfamily of Proteins
Figure 1
(a): Schematic representation of MyBP-C slow variants 1–4, showing their common structural motifs and novel insertions; white and grey ovals represent Ig and FN-III domains, respectively, while green, yellow, and red rectangles correspond to the NH2-terminal, Ig7, and COOH-terminal inserts, respectively. The NH2-terminal insert is present in variants 1 and 2, while the Ig7 and COOH-terminal inserts are present in variants 3 and 1, respectively. Variant 4 does not contain any of the three inserts. (b–d): Complex alternative splicing events result in the inclusion of exons 3 and 4, exon 23 and exon 31 that encode the NH2-terminal (b), Ig7 (c), and COOH-terminal (d) novel insertions. The amino acid and nucleotide compositions of the three insertions are shown.
