Skeletal Dysplasias Associated with Mild Myopathy—A Clinical and Molecular Review

Figure 5

Grip strength measurement in COMP-CTD T585M knock-in mice and COMP-T3 ΔD469 knock-in mice at 3 weeks of age. COMP-CTD mice were getting tired and let go of the apparatus easier than their wild type controls, although they were not generally weaker at 3 weeks of age, as seen by the maximum strengths registered (𝑛=15) [71]. COMP ∆D469 mice were not getting tired and had the same maximum strength as the wild type controls at 3 weeks of age; however, by 9 weeks they were significantly weaker than their wild type littermates and tired easier, which is indicative of a mild myopathy (𝑛=5). Key: wt: wild type, mut: homozygous for the mutation, ^∗𝑃<.05, ^∗∗𝑃<.01, ^∗∗∗𝑃<.001 (independent samples 𝑡-test).