Reconstruction of Protein-Protein Interaction Network of Insulin Signaling in Homo Sapiens

Table 1

Core proteins of the insulin signaling network.

Protein Symbol	Protein Name
AHSG	Alpha-2-HS-glycoprotein
AKT1	RAC-alpha serine/threonine-protein kinase
AKT2	RAC-beta serine/threonine-protein kinase
AP3S1	AP-3 complex subunit sigma-1
BAIAP2	Brain-specific angiogenesis inhibitor 1-associated protein 2
BCAR1	Breast cancer antiestrogen resistance protein 1
CILP	Cartilage intermediate layer protein 1
ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
FOXO4	Forkhead box protein O4
GAB1	GRB2-associated-binding protein 1
GRB2	Growth factor receptor-bound protein 2
GRB10	Growth factor receptor-bound protein 10
IGFBP5	Insulin-like growth factor-binding protein 5
IGF1	Insulin-like growth factor IA
IGF1R	Insulin-like growth factor 1 receptor
IGF2	Insulin-like growth factor II
IGF2R	Insulin-like growth factor type 2 receptor
INS	Insulin
INSR	Insulin receptor
IRS1	Insulin-receptor substrate 1
IRS2	Insulin-receptor substrate 2
PDPK1	3-phosphoinositide-dependent protein kinase 1
PHIP	PH-interacting protein
PIK3R1	Phosphatidylinositol 3-kinase regulatory subunit alpha
PIK3R3	Phosphatidylinositol 3-kinase regulatory subunit gamma
SIK2	Salt inducible protein kinase 2
SLC2A4 (GLUT4)	Solute carrier family 2, facilitated glucose transporter member 4
SOCS1	Suppressor of cytokine signaling 1
SORBS1	Sorbin and SH3 domain-containing protein 1
TSC2	Tuberin