Anti-Inflammatory Effects of Licorice and Roasted Licorice Extracts on TPA-Induced Acute Inflammation and Collagen-Induced Arthritis in Mice
Figure 2
Effects of LE and rLE on the progression and severity of CIA in mice. LE and rLE at 10 mg/kg were orally administered to CII-immunized mice once daily from day 25 to day 45. (a) The severity of arthritis was evaluated by clinical arthritis score and hind paw thickness. Data are expressed as mean ± SE of 5 mice per group. * versus vehicle-treated CIA mice. (b) Joint tissues from all mice were stained with H&E for histopathological examination (upper) and immunohistochemically stained for MMP-3 expression (lower).
