A Comprehensive In Silico Analysis of the Functional and Structural Impact of SNPs in the IGF1R Gene
Table 1
List of nsSNPs that were analysed by SIFT and PolyPhen.
dbSNP ID
Alleles
AA change
Tolerance index
PSIC
Heterozygosity
Validation
rs70958401
C/T
Arg/Trp
0.18
1.892
0.039
rs70958396
G/A
Ala/Thr
0.41
0.011
0.039
rs61740877
G/A
Val/Ile
0.77
0.019
n/a
rs61740868
C/T
Arg/Cys
0.00
2.609
n/a
1
rs61731172
G/A
Arg/Gln
0.74
0.137
n/a
rs56248469
G/A
Arg/His
0.57
0.613
n/a
rs45611935
A/G
Asn/Ser
0.77
0.387
n/a
rs45597432
T/C
Ile/Thr
0.96
0.079
n/a
rs45578132
T/C
Val/Ala
0.00
2.027
n/a
rs45553041
G/A
Arg/His
0.00
2.196
0.012
rs45526336
G/A
Glu/Lys
0.00
1.470
n/a
rs45524940
A/G
Thr/Ala
0.01
2.296
n/a
rs45522834
C/T
Thr/Ile
0.29
1.220
n/a
rs45512296
G/A
Arg/His
0.01
2.128
n/a
rs45504297
T/C
Leu/Pro
0.00
2.372
n/a
rs45493995
G/T
Ser/Ile
0.30
0.400
n/a
rs45475702
G/A
Val/Ile
0.55
0.296
n/a
rs45451896
G/T
Arg/Leu
0.25
0.305
n/a
rs45445894
G/A
Val/Met
0.03
0.947
0.011
rs35224135
G/A
Ala/Thr
0.31
1.026
0.005
2
rs34516635
G/A
Arg/His
1.00
1.339
0.005
1; 2
rs34102392
G/A
Ala/Thr
0.17
1.097
n/a
rs34061581
A/G
His/Arg
0.25
1.346
0.005
2
rs33958176
G/A
Arg/Gln
0.59
1.503
n/a
1; 2
Prediction scores found to be functionally significant by SIFT and PolyPhen are shown in bold.Validation Status Description: (1) validated by multiple, independent submissions to the refSNP cluster; (2) validated by frequency or genotype data: minor alleles observed in at least two chromosomes.
