Aquaporin Expression in Normal and Pathological Skeletal Muscles: A Brief Review with Focus on AQP4
Figure 2
Immunofluorescence with anti-AQP4 antibody of normal control muscle (a) and Duchenne muscular dystrophy muscle (DMD) (b), and that with anti-spectrin antibody of serial muscle section of DMD (c). Positive immunoreactivity with anti-AQP4 antibody is seen in apparently all myofibers of normal control muscles (a); while it is noted in mosaic pattern in DMD muscle (b). DMD muscle contains less numerous myofibers with positive immunoreactivity of anti-AQP4 antibody (b) than myofibers with that of anti-spectrin antibody (c). Scattered anti-AQP4 immunonegative fibers (asterisks in (b)) are noted in DMD muscle. Scale bar in (a)–(c) = 50 m.
