Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms
Model for differential cellular mechanics in human MSCs and osteoblasts. Thin and dense actin filaments in osteoblasts are tightly bound to the plasma membrane through multiple linker proteins (e.g, ATP-dependent ERM proteins) and focal complexes. Thicker stress fibers in human MSC are associated with the membrane mostly at the focal contacts due to a smaller contact area with the membrane and thus lower availability of protein linker binding sites. As result, in human MSC the overall membrane-cytoskeleton adhesion is weaker, and longer membrane tethers are formed that reflects a lower membrane tension. However, thick bundled actin structure in human MSCs provides a higher elastic modulus.
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