Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

Table 2

Risk for GGCCTT associated genotype in MMP-2 gene promoter in different CTCL stages compared to CTCL-Ia.

	MMP-2-GGCCTT (%)	MMP-2-the others (%)	Oddsratio^∗∗	P-value (𝑃corr^∗∗∗)
LPP^∗ (𝑁=23)	4 (17)	19 (83)	0.07 (0.01−0.28)	.00004 (0.0002)
CTCL-Ia (𝑁=23)	18 (77)	5 (23)
CTCL-Ib (𝑁=24)	10 (42)	14 (58)	0.10 (0.06−0.71)	.01 (0.02)
CTCL II (𝑁=11)	3 (25)	8 (75)	0.10 (0.02−0.55)	.007 (0.03)
CTCL III+IV (𝑁=8)	2 (30)	6 (70)	0.09 (0.01−0.61)	.01 (0.02)
Controls (𝑁=198)	100 (51)	98 (49)	0.28 (0.10−0.79)	.009 (0.03)

^∗LPP- large plaque parapsoriasis
^∗∗Odds ratio for GGCCTT in any group compared to CTCL-Ia (95% confidential interval)
^∗∗∗𝑃_corr  =  P-value corrected for multiple comparison.