Matrix Metalloproteinase-2 Promoter Genotype as a Marker of Cutaneous T-Cell Lymphoma Early Stage

Table 3

Risk for GGCCTT associated genotype in MMP-2 gene promoter in different CTCL stages compared to parapsoriasis.

	MMP-2-GGCCTT (%)	MMP-2-the others (%)	Oddsratio^∗	P-value (𝑃corr^∗∗)
LPP^∗ (𝑁=23)	4 (17)	19 (83)
CTCL-Ia (𝑁=23)	18 (77)	5 (23)	17.10 (3.95−73.95)	.00004 (0.0002)
CTCL-Ib (𝑁=24)	10 (42)	14 (58)	3.39 (0.88−13.08)	.07
CTCL II (𝑁=11)	3 (25)	8 (75)	1.78 (0.32−9.85)	.400
CTCL III+IV (𝑁=8)	2 (30)	6 (70)	1.58 (0.23−10.90)	.497
Controls (𝑁=198)	100 (51)	98 (49)	4.85 (1.59−14.76)	.002 (0.008)

^∗LPP - large plaque parapsoriasis
^∗∗Odds ratio for GGCCTT in any group compared to LPP (95% confidential interval)
^∗∗∗𝑃_{𝑐𝑜𝑟𝑟} =P-value corrected for multiple comparison.