RNAi-Based Strategies for Cyclooxygenase-2 Inhibition in Cancer

Table 2

Anti-COX-2 miRNAs.

Study	miRNAs	Model	Function	Ref
Chakrabarty et al. 2007	mmu-miR 199a^∗ mmu-miR-101a	mouse	- Correlate inversely with COX-2 protein	[57]
			during embryo implantation
			- Regulate COX-2 protein expression
Daikoku et al. 2008	mmu-miR-199a^∗ mmu-miR-101a	mouse	- Correlate inversely with COX-2 protein	[58]
			in endometrial cancer cells
Strillacci et al. 2008	hsa-miR-101	homo	- Correlates inversely with COX-2 protein	[59]
			in colon cancer cells
			- Regulates COX-2 protein expression
			(translational repression)
Shanmugam et al. 2008	hsa-miR-16	homo	- Promotes COX-2 mRNA degradation in	[60]
			THP-1 monocytic cells