Tomatine Adjuvantation of Protective Immunity to a Major Pre-erythrocytic Vaccine Candidate of Malaria is Mediated via T Cell Release of IFN-
Type 1 cytokine production by splenocytes from mice immunized with adjuvant-antigen preparations of tomatine-P. berghei CS peptide or tomatine-saline following ex vivo restimulation with P. berghei CS peptide (25 g/mL). Control cytokine production of similarly stimulated splenocytes from naive mice is also shown. Data represent fold increases in secretion of each cytokine over that of splenocytes from identically immunized mice within each group but which were not restimulated ex vivo (absolute levels shown in italics). Data shown represent the mean of four mice, assayed individually in triplicate, from one of four similar experiments. IFN- production (shown in bold): versus tomatine-saline group; versus naive group, determined by the Mann-Whitney-test.
Unstimulated cells (pg/mL)
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