Review Article
IL-10 and TNFα Genotypes in SLE
Table 1
Main functional IL-10 and TNF SNPs involved in SLE.
| | IL-10 | TNF |
| Functional polymorphism | A/G | G/A | rs number | 1800896 | 1800629 | High producer allele | G* | A* | Population frequency of high producer allele | | | North/Centre European and North American [32, 40, 44, 46] | 0.43–0.52 | 0.11–0.17 | South European [30, 36, 39, 45] | 0.29–0.40 | 0.12–0.14 | South American [31, 37, 38, 42] | 0.29–0.35 | 0.08–0.03 | Asian [29, 34, 35, 41, 43] | 0.04–0.06 | 0.10–0.14 |
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Ranges of allele frequency in healthy population.
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