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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 838530, 8 pages
http://dx.doi.org/10.1155/2010/838530
Research Article

Dynamic Strength of Titin's Z-Disk End

1Department of Biophysics, Faculty of Medicine, University of Pécs, Szigeti ut 12., Pécs 7624, Hungary
2Department of Biophysics and Radiation Biology, Faculty of Medicine, Semmelweis University, Tűzoltó u. 37-47., Budapest 1094, Hungary

Received 7 December 2009; Accepted 11 February 2010

Academic Editor: Henk L. M. Granzier

Copyright © 2010 Veronika Kollár et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. C. Gregorio, H. Granzier, H. Sorimachi, and S. Labeit, “Muscle assembly: a titanic achievement?” Current Opinion in Cell Biology, vol. 11, no. 1, pp. 18–25, 1999. View at Publisher · View at Google Scholar · View at Scopus
  2. K. Maruyama, “Connectin/titin, giant elastic protein of muscle,” FASEB Journal, vol. 11, no. 5, pp. 341–345, 1997. View at Google Scholar · View at Scopus
  3. K. Wang, “Titin/connectin and nebulin: giant protein rulers of muscle structure and function,” Advances in Biophysics, vol. 33, pp. 123–134, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. T. Funatsu, H. Higuchi, and S. Ishiwata, “Elastic filaments in skeletal muscle revealed by selective removal of thin filaments with plasma gelsolin,” Journal of Cell Biology, vol. 110, no. 1, pp. 53–62, 1990. View at Publisher · View at Google Scholar · View at Scopus
  5. H. L. Granzier and T. C. Irving, “Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments,” Biophysical Journal, vol. 68, no. 3, pp. 1027–1044, 1995. View at Google Scholar · View at Scopus
  6. R. Horowits, E. S. Kempner, M. E. Bisher, and R. J. Podolsky, “A physiological role for titin and nebulin in skeletal muscle,” Nature, vol. 322, no. 6084, pp. 160–164, 1986. View at Google Scholar · View at Scopus
  7. W. A. Linke, M. Ivemeyer, N. Olivieri, B. Kolmerer, J. C. Rüegg, and S. Labeit, “Towards a molecular understanding of the elasticity of titin,” Journal of Molecular Biology, vol. 261, no. 1, pp. 62–71, 1996. View at Publisher · View at Google Scholar · View at Scopus
  8. H. Yajima, H. Ohtsuka, Y. Kawamura et al., “A 11.5-kb 5'-terminal cDNA sequence of chicken breast muscle connectin/titin reveals its Z line binding region,” Biochemical and Biophysical Research Communications, vol. 223, no. 1, pp. 160–164, 1996. View at Publisher · View at Google Scholar · View at Scopus
  9. M. Gautel, D. Goulding, B. Bullard, K. Weber, and D. O. Fürst, “The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers,” Journal of Cell Science, vol. 109, no. 11, pp. 2747–2754, 1996. View at Google Scholar · View at Scopus
  10. M.-L. Bang, T. Centner, F. Fornoff et al., “The complete gene sequence of titin, expression of an unusual ˜700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system,” Circulation Research, vol. 89, no. 11, pp. 1065–1072, 2001. View at Google Scholar · View at Scopus
  11. H. Sorimachi, A. Freiburg, B. Kolmerer et al., “Tissue-specific expression and a-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs,” Journal of Molecular Biology, vol. 270, no. 5, pp. 688–695, 1997. View at Publisher · View at Google Scholar · View at Scopus
  12. R. A. Atkinson, C. Joseph, F. Dal Piaz et al., “Binding of a-actinin to titin: implications for Z-disk assembly,” Biochemistry, vol. 39, no. 18, pp. 5255–5264, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. P. Young, C. Ferguson, S. Bañuelos, and M. Gautel, “Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of α-actinin,” The EMBO Journal, vol. 17, no. 6, pp. 1614–1624, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. J. O. Vigoreaux, “The muscle Z band: lessons in stress management,” Journal of Muscle Research and Cell Motility, vol. 15, no. 3, pp. 237–255, 1994. View at Google Scholar · View at Scopus
  15. D. Frank, C. Kuhn, H. A. Katus, and N. Frey, “Role of the sarcomeric Z-disc in the pathogenesis of cardiomyopathy,” Future Cardiology, vol. 3, no. 6, pp. 611–622, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. W. G. Pyle and R. J. Solaro, “At the crossroads of myocardial signaling: the role of Z-discs in intracellular signaling and cardiac function,” Circulation Research, vol. 94, no. 3, pp. 296–305, 2004. View at Publisher · View at Google Scholar · View at Scopus
  17. W. A. Linke, “Sense and stretchability: the role of titin and titin-associated proteins in myocardial stress-sensing and mechanical dysfunction,” Cardiovascular Research, vol. 77, no. 4, pp. 637–648, 2008. View at Publisher · View at Google Scholar · View at Scopus
  18. M. K. Miller, H. Granzier, E. Ehler, and C. C. Gregorio, “The sensitive giant: the role of titin-based stretch sensing complexes in the heart,” Trends in Cell Biology, vol. 14, no. 3, pp. 119–126, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. G. Valle, G. Faulkner, A. De Antoni et al., “Telethonin, a novel sarcomeric protein of heart and skeletal muscle,” FEBS Letters, vol. 415, no. 2, pp. 163–168, 1997. View at Publisher · View at Google Scholar · View at Scopus
  20. C. C. Gregorio, K. Trombitás, T. Centner et al., “The NH2 terminus of titin spans the Z-disc: its interaction with a novel 19-kD ligand (T-cap) is required for sarcomeric integrity,” Journal of Cell Biology, vol. 143, no. 4, pp. 1013–1027, 1998. View at Publisher · View at Google Scholar · View at Scopus
  21. E. S. Moreira, T. J. Wiltshire, G. Faulkner et al., “Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin,” Nature Genetics, vol. 24, no. 2, pp. 163–166, 2000. View at Publisher · View at Google Scholar · View at Scopus
  22. R. Knöll, M. Hoshijima, H. M. Hoffman et al., “The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy,” Cell, vol. 111, no. 7, pp. 943–955, 2002. View at Publisher · View at Google Scholar · View at Scopus
  23. J. M. Bos, R. N. Poley, M. Ny et al., “Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin,” Molecular Genetics and Metabolism, vol. 88, no. 1, pp. 78–85, 2006. View at Publisher · View at Google Scholar · View at Scopus
  24. C. Geier, A. Perrot, C. Özcelik et al., “Mutations in the human muscle LIM protein gene in families with hypertrophic cardiomyopathy,” Circulation, vol. 107, no. 10, pp. 1390–1395, 2003. View at Publisher · View at Google Scholar · View at Scopus
  25. A. Mues, P. F. M. van der Ven, P. Young, D. O. Fürst, and M. Gautel, “Two immunoglobulin-like domains of the Z-disc portion of titin interact in a conformation-dependent way with telethonin,” FEBS Letters, vol. 428, no. 1-2, pp. 111–114, 1998. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Marino, P. Zou, D. Svergun et al., “The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin,” Structure, vol. 14, no. 9, pp. 1437–1447, 2006. View at Publisher · View at Google Scholar · View at Scopus
  27. E. H. Lee, J. Hsin, O. Mayans, and K. Schulten, “Secondary and tertiary structure elasticity of titin Z1Z2 and a titin chain model,” Biophysical Journal, vol. 93, no. 5, pp. 1719–1735, 2007. View at Publisher · View at Google Scholar · View at Scopus
  28. P. Zou, M. Gautel, A. Geerlof, M. Wilmanns, M. H. J. Koch, and D. I. Svergun, “Solution scattering suggests cross-linking function of telethonin in the complex with titin,” Journal of Biological Chemistry, vol. 278, no. 4, pp. 2636–2644, 2003. View at Publisher · View at Google Scholar · View at Scopus
  29. P. Zou, N. Pinotsis, S. Lange et al., “Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk,” Nature, vol. 439, no. 7073, pp. 229–233, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. E. H. Lee, M. Gao, N. Pinotsis, M. Wilmanns, and K. Schulten, “Mechanical strength of the titin Z1Z2-telethonin complex,” Structure, vol. 14, no. 3, pp. 497–509, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. M. Bertz, M. Wilmanns, and M. Rief, “The titin-telethonin complex is a directed, superstable molecular bond in the muscle Z-disk,” Proceedings of the National Academy of Sciences of the United States of America, vol. 106, no. 32, pp. 13307–13310, 2009. View at Publisher · View at Google Scholar · View at Scopus
  32. L. Grama, A. Nagy, C. Scholl, T. Huber, and M. S. Z. Kellermayer, “Local variability in the mechanics of titin's tandem Ig segments,” Croatica Chemica Acta, vol. 78, no. 3, pp. 405–411, 2005. View at Google Scholar · View at Scopus
  33. S. Labeit and B. Kolmerer, “Titins: giant proteins in charge of muscle ultrastructure and elasticity,” Science, vol. 270, no. 5234, pp. 293–296, 1995. View at Google Scholar · View at Scopus
  34. A. Nagy, L. Grama, T. Huber et al., “Hierarchical extensibility in the PEVK domain of skeletal-muscle titin,” Biophysical Journal, vol. 89, no. 1, pp. 329–336, 2005. View at Publisher · View at Google Scholar · View at Scopus
  35. J. L. Hutter and J. Bechhoefer, “Calibration of atomic-force microscope tips,” Review of Scientific Instruments, vol. 64, no. 7, pp. 1868–1873, 1993. View at Publisher · View at Google Scholar · View at Scopus
  36. G. I. Bell, “Models for the specific adhesion of cells to cells,” Science, vol. 200, no. 4342, pp. 618–627, 1978. View at Publisher · View at Google Scholar · View at Scopus
  37. E. Evans and K. Ritchie, “Dynamic strength of molecular adhesion bonds,” Biophysical Journal, vol. 72, no. 4, pp. 1541–1555, 1997. View at Google Scholar · View at Scopus
  38. M. S. Z. Kellermayer, S. B. Smith, H. L. Granzier, and C. Bustamante, “Folding-unfolding transitions in single titin molecules characterized with laser tweezers,” Science, vol. 276, no. 5315, pp. 1112–1116, 1997. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Rief, J. M. Fernandez, and H. E. Gaub, “Elastically coupled two-level systems as a model for biopolymer extensibility,” Physical Review Letters, vol. 81, no. 21, pp. 4764–4767, 1998. View at Google Scholar · View at Scopus
  40. H. Dietz, M. Bertz, M. Schlierf et al., “Cysteine engineering of polyproteins for single-molecule force spectroscopy,” Nature Protocols, vol. 1, no. 1, pp. 80–84, 2006. View at Publisher · View at Google Scholar · View at Scopus
  41. H. Dietz and M. Rief, “Exploring the energy landscape of GFP by single-molecule mechanical experiments,” Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 46, pp. 16192–16197, 2004. View at Publisher · View at Google Scholar · View at Scopus
  42. L. Grama, A. Málnási-Csizmadia, and C. R. Bagshaw, “Mechanical characterization of single green fluorescent protein homopolymer molecules,” Biophysical Journal, vol. 82, no. 193a, 2002. View at Google Scholar
  43. H. Li, W. A. Linke, A. F. Oberhauser et al., “Reverse engineering of the giant muscle protein titin,” Nature, vol. 418, no. 6901, pp. 998–1002, 2002. View at Publisher · View at Google Scholar · View at Scopus
  44. H. Li, A. F. Oberhauser, S. B. Fowler, J. Clarke, and J. M. Fernandez, “Atomic force microscopy reveals the mechanical design of a modular protein,” Proceedings of the National Academy of Sciences of the United States of America, vol. 97, no. 12, pp. 6527–6531, 2000. View at Publisher · View at Google Scholar · View at Scopus
  45. D. J. Brockwell, G. S. Beddard, J. Clarkson et al., “The effect of core destabilization on the mechanical resistance of 127,” Biophysical Journal, vol. 83, no. 1, pp. 458–472, 2002. View at Google Scholar · View at Scopus
  46. M. Rief, M. Gautel, H. E. Gaub et al., “Unfolding forces of titin and fibronectin domains directly measured by AFM,” Advances in Experimental Medicine and Biology, vol. 481, pp. 129–141, 2000. View at Google Scholar · View at Scopus
  47. J. Trinick, “Gytoskeleton titin as a scaffold and spring,” Current Biology, vol. 6, no. 3, pp. 258–260, 1996. View at Google Scholar · View at Scopus