|
Stem cell system | DNA repair mechanism/enzyme | Higher | Similar | Lower | Remarks | Ref. |
|
ESC |
|
Human ESC | Expression of double strand break repair genes | √ | | | Compared to human embryoid bodies and fibroblasts | [5] |
|
Human ESC | Expression of BER genes | √ | | | Compared to human embryoid bodies and fibroblasts | [5] |
|
Human ESC | Expression of NER genes | √ | | | Compared to human embryoid bodies and fibroblasts | [5] |
|
Human ESC | Expression of antioxidant and DNA repair genes | √ | | | Compared to differentiated cells | [10] |
|
Murine ESC | Expression of strand break repair genes | √ | | | Compared to differentiated cells | [1, 2] |
|
Murine ESC | Expression of antioxidant and strand break repair genes | √ | | | Compared to differentiated cells | [13] |
|
Murine ESC | NER | | | √ | Strong apoptosis | [16] |
|
Murine ESC | NER | | | √ | Strong apoptosisS-phase delay | [17] |
|
Murine ESC | MGMTMMR | √ | | | Compared to differentiated cells Highly sensitive to methylation damageStrong apoptosis | [14] |
|
ASC |
|
Human CD34+ 38− hematopoietic stem cells | Removal of ENU or melphalan-induced DNA adducts | √ | | | Compared to progenitor or mature cellsResistant to DNA-reactive drugs | [20] |
|
Human CD34+ 38− hematopoietic stem cells | Resealing of strand breaks and repair gaps | √ | | | Compared to progenitor or mature cellsResistant to DNA-reactive drugs | [20] |
|
Human CD 34+ hematopoietic stem cells | KU70 expression | √ | | | Negatively correlated with donor age | [21] |
|
Human cells of the monocytic lineage | NER | √ | | | Compared to macrophages | [22] |
|
Human neural precursors | NER | √ | | | Compared to neurons | [23, 24] |
|
Human cycling CD34+ hematopoietic stem cells | MGMTMMR | | √ | | Compared to mature CD34− cellsNormally sensitive to methylation damage | [25] |
|
Murine neural precursors | | | | √ | Sensitive to IR | [26] |
|
Stem cells in the subventricular zone and oligodendrocyte precursor cells in rodent and human brain | | | | √ | Sensitive to IR | [27] |
|
Murine neural stem/progenitor cells | BER (OGG1) | √ | | | Compared to differentiated cells | [28] |
Murine neural stem/progenitor cells | BER (NEIL3) | √ | | | Compared to differentiated cells | [29, 30] |
|
Murine fetal hematopoietic cells | BER (DNA pol β) | | | √ | Compared to adult hematopoietic cellsLow point mutation frequency | [31] |
|
Murine myoblasts | BER (DNA ligase I and XRCC1) | √ | | | Compared to myotubes | [32] |
|
Murine keratinocytes | NER | | √ | | | [33] |
|
MSC |
|
Human fetal MSC | DNA repair gene expression | √ | | | Compared to adult MSC | [34] |
|
Human MSC from bone marrow transplantation patients | DSB repair | √ | | | Compared to lung or breast cancer cellsResistant to IR | [35] |
|
Human MSC obtained from bone marrow transplantation patients | ROS-scavenging capacity | √ | | | Resistant to IR | [35] |
|
Human MSC | Single and double-strand break repair | | √ | | Resistant to IRHigh telomerase activity | [36] |
|
Rat MSC | DNA repair gene expression | √ | | | Compared to senescent MSC | [9] |
|