The Bright and the Dark Sides of DNA Repair in Stem Cells

Table 2

Stem cell involvement in high grade glioma patient’s outcome.

Stem cell marker	Clinical model	Animal model	Association to poor outcome		Ref.
CD133	Human bulk gliomas		Yes		[43]
CD133	Gliomas of various grade and histology		Yes		[44]
CD133	Low-grade and high-grade glioma specimens		Yes		[45]
CD133	Cell lines from GBM specimens established under neural stem cell conditions		Yes		[46]
CD133	U251 human glioma cells with knocked-down CD133		Yes		[47]
CD133	Two types of GSC within different regions of the same human GBM			No	[48]
Expression signature dominated by HOX genes, which comprises CD133	GBM from initial surgery or resected at recurrence		Yes		[49]
CD133, Nestin, Sox-2, Musashi-1, CXCR4, Flt-4/VEGFR-3 and CD105/Endoglin	Astrocytomas of different WHO grades		Yes		[50]
Sox2, Musashi-1, nestin	Surgical specimens of human gliomatosis cerebri		Yes		[51]
Renewable neurosphere formation	Cultured human gliomas		Yes		[52]
CD133		Mouse line whose CD133-expressing cells can be eliminated conditionally		No	[53]
CD133		Rat C6 cell line		No	[54]
CD133, nestin		Rat N29 and N32 experimental gliomas	Yes		[55]