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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 851589, 7 pages
Research Article

The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

1Department of Biology, Faculty of Science, Gebze Institute of Technology, Gebze 41400, Kocaeli, Turkey
2Department of Clinical Biochemistry, Erciyes University, 38039 Kayseri, Turkey
3Istanbul Centro Laboratories, 34400 İstanbul, Turkey

Received 28 December 2009; Revised 21 March 2010; Accepted 25 March 2010

Academic Editor: Michael Kalafatis

Copyright © 2010 A. Demiroglu-Zergeroglu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Malignant Mesothelioma (MM) is an aggressive and lethal tumour of the serosal surfaces with poor prognosis. In this study, we have investigated the antiproliferative effect of Quercetin (QU) and its combination with Cisplatin (CIS) on SPC212 and SPC111 cell lines. Our experiments showed that QU significantly reduced the proliferation of cell lines, altered the cell cycle distribution, and increased the level of Caspase 9 (C9) and Caspase 3 (C3) in concentration and time-dependent manner. Additionally, the combination of QU + CIS was found more effective when compared with individual treatment of agents.