BioMed Research International

Research Article

The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro

Figure 2

SPC212 (a) and SPC111 (b) cells were untreated and treated with 5  πœ‡ g/ml CIS, 10  πœ‡ g/mL CIS, 50  πœ‡ M QU and 5  πœ‡ g/mL CIS + 50  πœ‡ M QU, and 10  πœ‡ g/mL CIS + 50  πœ‡ M QU for 0–96 hours. Cell proliferation decrease imposed by QU, CIS, and QU + CIS was time dependent. Combination treatments were found more effective than individual treatments in SPC212 cells in 96 hours (a). Additionally, both individual and combination applications reduced cell proliferation in SPC111 cells when compared with untreated cells in 96 hours (b); however no significant differences were observed on the reduction of cell proliferation when compared with combined and individual treatments in 96 hours. Data was statistically evaluated between control group, single dose groups, and combination dose groups, with the level of significance chosen as βˆ— 𝑃 ≀ . 0 5 ; βˆ— βˆ— 𝑃 ≀ . 0 1 , and # 𝑃 < . 0 5 between QU + CIS treatment and CIS alone.
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851589.fig.002b
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