Table of Contents Author Guidelines Submit a Manuscript
Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 858606, 8 pages
Review Article

Assembly and Dynamics of Myofibrils

Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA

Received 31 December 2009; Accepted 15 March 2010

Academic Editor: Aikaterini Kontrogianni-Konstantopoulos

Copyright © 2010 Joseph W. Sanger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We review some of the problems in determining how myofibrils may be assembled and just as importantly how this contractile structure may be renewed by sarcomeric proteins moving between the sarcomere and the cytoplasm. We also address in this personal review the recent evidence that indicates that the assembly and dynamics of myofibrils are conserved whether the cells are analyzed in situ or in tissue culture conditions. We suggest that myofibrillogenesis is a fundamentally conserved process, comparable to protein synthesis, mitosis, or cytokinesis, whether examined in situ or in vitro.