Bioinformatics in New Generation Flavivirus Vaccines
Figure 1
(a) Flavivirus genomic RNA encoding one long ORF cleaved co- and post-translationally into three structural and seven nonstructural proteins. The viral genome is flanked by and UTRs which play an important role in virus transcription and replication. (b) Three dimensional structure of the monomeric form of the E protein of DENV-2. Each monomer is divided into three discernable domains (DI, II and III). Serocomplex and group specific cross reactive epitopes are mainly located on DI and II. DIII is the receptor binding domain and contains mainly type specific epitopes. The potent neutralizing epitopes are located at the lateral site of DIII.
