Bioinformatics in New Generation Flavivirus Vaccines
Figure 3
Prediction of RNA secondary structure of the UTR of DENV-3 strain H87 (DENV-2 Jamaica strain) using the GA algorithm included in the STAR software package. In the top panel is depicted the predicted structure of the naturally occurring strain (shown with arrows the predicted pseudoknot and the conserved LSH structures), bottom panel: predicted structure after in silico introduction of a 29-nt deletion in the proximal part of the UTR. The LSH is preserved but the pseudoknot is lost after deletion. LSH: long stable hairpin, ps: pseudoknot.
