The Receptor for Advanced Glycation End Products (RAGE) and the Lung

Figure 3

RAGE is central to many fundamental biological processes in the lung. Expression of RAGE has been shown to promote spreading of adherent cells on collagen IV and in doing so may ensure effective gas exchange. RAGE-expressing epithelial cells exhibit diminished proliferative capacity compared to non-expressing cells. Cells overexpressing RAGE adhere much faster to collagen IV, and to a greater extent when compared to mock transfected cells suggesting an important role in cell-extracellular matrix interactions.