Hypomethylation of IL10 and IL13 Promoters in CD4⁺ T Cells of Patients with Systemic Lupus Erythematosus

Figure 3

IL10 enhancer methylation patterns in CD4⁺ T cells from SLE patients and healthy controls. (a) The mean methylation status for each of the 8 CG pairs within intron 4 of the IL10 locus in CD4⁺ T cells from healthy controls (𝑛=10; upper panel) and SLE patients (𝑛=10; lower panel). (b) The combined average methylation status of 7 CG pairs (positions +3144, +3162, +3170, +3200, +3229, +3261, and +3265) in IL10 intron 4 in SLE CD4⁺ T cells was lower than healthy controls (𝑃=.036). (c) Average IL10 promoter DNA methylation status correlated (𝑟=−0.432) with relative mRNA level in SLE patients (𝑃=.040).

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