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Journal of Biomedicine and Biotechnology
Volume 2010, Article ID 953537, 17 pages
http://dx.doi.org/10.1155/2010/953537
Review Article

Nanotargeted Radionuclides for Cancer Nuclear Imaging and Internal Radiotherapy

1Center of Nanomedicine and National Institute of Cancer Research, National Health Research Institutes, 35053 Miaoli, Taiwan
2Isotope Application Division, Institute of Nuclear Energy Research, 32546 Taoyuan, Taiwan
3Biomedical Imaging and Radiological Sciences, National Yang-Ming University, 11221 Taipei, Taiwan

Received 13 April 2010; Accepted 15 June 2010

Academic Editor: David J. Yang

Copyright © 2010 Gann Ting et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [58 citations]

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  • Joanna Kazmierska, “New technology in radiotherapy,” European Journal of Cancer, vol. 47, pp. S322–S323, 2011. View at Publisher · View at Google Scholar
  • Ondrej Sedlacek, Martin Hruby, Martin Studenovsky, Jan Kucka, David Vetvicka, Lubomir Kovar, Blanka Rihova, and Karel Ulbrich, “Ellipticine-Aimed Polymer-Conjugated Auger Electron Emitter: Multistage Organelle Targeting Approach,” Bioconjugate Chemistry, vol. 22, no. 6, pp. 1194–1201, 2011. View at Publisher · View at Google Scholar
  • Ali, Abbasi, Zhang, Arosio, Lascialfari, Casula, Wenk, Kreyling, Plapper, Seidel, Niessner, Knöll, Seubert, and Parak, “Multifunctional nanoparticles for dual imaging,” Analytical Chemistry, vol. 83, no. 8, pp. 2877–2882, 2011. View at Publisher · View at Google Scholar
  • Feng-Yun J. Huang, Te-Wei Lee, Chih-Hao K. Kao, Chih-Hsien Chang, Xiaoning Zhang, Wan-Yu Lee, Wan-Jou Chen, Shu-Chi Wang, and Jem-Mau Lo, “ Imaging, Autoradiography, and Biodistribution of 188 Re-Labeled PEGylated Nanoliposome in Orthotopic Glioma Bearing Rat Model ,” Cancer Biotherapy & Radiopharmaceuticals, vol. 26, no. 6, pp. 717–725, 2011. View at Publisher · View at Google Scholar
  • Jose A. Barreto, Madlen Matterna, Bim Graham, Holger Stephan, and Leone Spiccia, “Synthesis, colloidal stability and Cu-64 labeling of iron oxide nanoparticles bearing different macrocyclic ligands,” New Journal Of Chemistry, vol. 35, no. 11, pp. 2705–2712, 2011. View at Publisher · View at Google Scholar
  • Chih-Hsien Chang, Ya-Jen Chang, Te-Wei Lee, Gann Ting, and Kwo-Ping Chang, “Dosimetric evaluation of nanotargeted Re-188-liposome with the MIRDOSE3 and OLINDA/EXM programs,” Annals Of Nuclear Medicine, vol. 26, no. 5, pp. 419–425, 2012. View at Publisher · View at Google Scholar
  • Mine Silindir, Suna Erdoğan, A. Yekta Özer, and Serge Maia, “Liposomes and their applications in molecular imaging,” Journal of Drug Targeting, vol. 20, no. 5, pp. 401–415, 2012. View at Publisher · View at Google Scholar
  • Vivek Patel, Rao V. L. Papineni, Seema Gupta, Radka Stoyanova, and Mansoor M. Ahmed, “A realistic utilization of nanotechnology in molecular imaging and targeted radiotherapy of solid tumors,” Radiation Research, vol. 177, no. 4, pp. 483–495, 2012. View at Publisher · View at Google Scholar
  • Oren Giladi, and Simon Benita, “Immunonanoparticles for Nuclear Imaging and Radiotherapy,” Antibody-Mediated Drug Delivery Systems, pp. 427–456, 2012. View at Publisher · View at Google Scholar
  • Misty Muscarella, and Yashwant Pathak, “Targeted Nanoparticles in Radiotherapy,” Antibody-Mediated Drug Delivery Systems, pp. 105–128, 2012. View at Publisher · View at Google Scholar
  • Dimitrios Psimadas, Panagiotis Georgoulias, Varvara Valotassiou, and George Loudos, “Molecular nanomedicine towards cancer: 111In-labeled nanoparticles,” Journal of Pharmaceutical Sciences, vol. 101, no. 7, pp. 2271–2280, 2012. View at Publisher · View at Google Scholar
  • Yongjian Liu, and Michael J. Welch, “Nanoparticles labeled with positron emitting nuclides: Advantages, methods, and applications,” Bioconjugate Chemistry, vol. 23, no. 4, pp. 671–682, 2012. View at Publisher · View at Google Scholar
  • Geetanjali Arora, Jaya Shukla, Sourabh Ghosh, Subir Kumar Maulik, Arun Malhotra, and Gurupad Bandopadhyaya, “Plga nanoparticles for peptide receptor radionuclide therapy of neuroendocrine tumors: A novel approach towards reduction of renal radiation dose,” PLoS ONE, vol. 7, no. 3, 2012. View at Publisher · View at Google Scholar
  • Martin Hruby, “Nano-sized Carrier Systems as New Materials for Nuclear Medicine,” Intelligent Nanomaterials, pp. 715–739, 2012. View at Publisher · View at Google Scholar
  • Milad Pourbaghi-Masouleh, Claudio Tenreiro, Mohamadreza K. Bakht, and Mahdi Sadeghi, “Scope of Nanotechnology-based Radiation Therapy and Thermotherapy Methods in Cancer Treatment,” Current Cancer Drug Targets, vol. 12, no. 8, pp. 998–1015, 2012. View at Publisher · View at Google Scholar
  • Wen-Chuan Lee, Chih-Hsien Chang, Chih-Min Huang, Yu-Tse Wu, Liang-Cheng Chen, Chung-Li Ho, Tsui-Jung Chang, Te-Wei Lee, and Tung-Hu Tsai, “Correlation between radioactivity and chemotherapeutics of the In-111-VNB-liposome in pharmacokinetics and biodistribution in rats,” International Journal Of Nanomedicine, vol. 7, pp. 683–692, 2012. View at Publisher · View at Google Scholar
  • Liang-Cheng Chen, Yu-Hsien Wu, I-Hshiang Liu, Chung-Li Ho, Wan-Chi Lee, Chih-Hsien Chang, Keng-Li Lan, Gann Ting, Te-Wei Lee, and Jui-Hung Shien, “Pharmacokinetics, dosimetry and comparative efficacy of 188Re-liposome and 5-FU in a CT26-luc lung-metastatic mice model,” Nuclear Medicine and Biology, vol. 39, no. 1, pp. 35–43, 2012. View at Publisher · View at Google Scholar
  • S.M. Qaim, “The present and future of medical radionuclide production,” Radiochimica Acta, vol. 100, no. 8-9, pp. 635–651, 2012. View at Publisher · View at Google Scholar
  • Claire Vanpouille-Box, and François Hindré, “Nanovectorized radiotherapy: a new strategy to induce anti-tumor immunity.,” Frontiers in oncology, vol. 2, pp. 136, 2012. View at Publisher · View at Google Scholar
  • Dimitrios Psimadas, Penelope Bouziotis, Panagiotis Georgoulias, Varvara Valotassiou, Theodoros Tsotakos, and George Loudos, “Radiolabeling approaches of nanoparticles with 99mTc,” Contrast Media and Molecular Imaging, vol. 8, no. 4, pp. 333–339, 2013. View at Publisher · View at Google Scholar
  • Tadahiro Kin, Yasuki Nagai, Nobuyuki Iwamoto, Futoshi Minato, Osamu Iwamoto, Yuichi Hatsukawa, Mariko Segawa, Hideo Harada, Chikara Konno, Kentaro Ochiai, and Kosuke Takakura, “ New Production Routes for Medical Isotopes 64 Cu and 67 Cu Using Accelerator Neutrons ,” Journal of the Physical Society of Japan, vol. 82, no. 3, pp. 034201, 2013. View at Publisher · View at Google Scholar
  • George C. Nikiforidis, George C. Kagadis, Irene Tsiapa, George Loudos, Alexandra Varvarigou, Eirini Fragogeorgi, Dimitrios Psimadas, Theodoros Tsotakos, Stavros Xanthopoulos, Dimitris Mihailidis, and Penelope Bouziotis, “Biological evaluation of an ornithine-modified 99mTc-labeled RGD peptide as an angiogenesis imaging agent,” Nuclear Medicine and Biology, vol. 40, no. 2, pp. 262–272, 2013. View at Publisher · View at Google Scholar
  • Agata Piotrowska, Edyta Leszczuk, Frank Bruchertseifer, Alfred Morgenstern, and Aleksander Bilewicz, “Functionalized NaA nanozeolites labeled with 224,225Ra for targeted alpha therapy,” Journal of Nanoparticle Research, vol. 15, no. 11, 2013. View at Publisher · View at Google Scholar
  • Rafael G. Mendes, Alicja Bachmatiuk, Bernd Büchner, Gianaurelio Cuniberti, and Mark H. Rümmeli, “Carbon nanostructures as multi-functional drug delivery platforms,” Journal of Materials Chemistry B, vol. 1, no. 4, pp. 401, 2013. View at Publisher · View at Google Scholar
  • Deepa Narayanan, R. Jayakumar, and K. P. Chennazhi, “Versatile carboxymethyl chitin and chitosan nanomaterials: a review,” Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, vol. 6, no. 6, pp. 574–598, 2014. View at Publisher · View at Google Scholar
  • Helen Lee, Jinzi Zheng, Daniel Gaddy, Kelly D. Orcutt, Shannon Leonard, Elena Geretti, Jacob Hesterman, Catey Harwell, Jack Hoppin, David A. Jaffray, Thomas Wickham, Bart S. Hendriks, and Dmitri Kirpotin, “A gradient-loadable 64Cu-chelator for quantifying tumor deposition kinetics of nanoliposomal therapeutics by positron emission tomography,” Nanomedicine: Nanotechnology, Biology and Medicine, 2014. View at Publisher · View at Google Scholar
  • Sam J. Popwell, Michael D. Schulz, Kenneth B. Wagener, Christopher D. Batich, Rowan J. Milner, Joanne Lagmay, and Wesley E. Bolch, “Synthesis of Polymeric Phosphonates for Selective Delivery of Radionuclides to Osteosarcoma,” Cancer Biotherapy & Radiopharmaceuticals, pp. 140811063337002, 2014. View at Publisher · View at Google Scholar
  • Irene Tsiapa, Eleni K. Efthimiadou, Eirini Fragogeorgi, George Loudos, Alexandra D. Varvarigou, Penelope Bouziotis, George C. Kordas, Dimitris Mihailidis, George C. Nikiforidis, Stavros Xanthopoulos, Dimitrios Psimadas, Maria Paravatou-Petsotas, Lazaros Palamaris, John D. Hazle, and George C. Kagadis, “‘99mTc-Labeled aminosilane-coated iron oxide nanoparticles for molecular imaging of ανβ3 –mediated tumor expression and feasibility for hyperthermia treatment’,” Journal of Colloid and Interface Science, 2014. View at Publisher · View at Google Scholar
  • Karina Pombo Garcia, Kristof Zarschler, Lisa Barbaro, Jose A. Barreto, William O'Malley, Leone Spiccia, Holger Stephan, and Bim Graham, “Zwitterionic-Coated "Stealth" Nanoparticles for Biomedical Applications: Recent Advances in Countering Biomolecular Corona Formation and Uptake by the Mononuclear Phagocyte System,” Small, vol. 10, no. 13, pp. 2516–2529, 2014. View at Publisher · View at Google Scholar
  • Nozomi Sato, Kazuaki Tsukada, Satoshi Watanabe, Noriko S. Ishioka, Masako Kawabata, Hideya Saeki, Yasuki Nagai, Tadahiro Kin, Futoshi Minato, Nobuyuki Iwamoto, and Osamu Iwamoto, “ First Measurement of the Radionuclide Purity of the Therapeutic Isotope 67 Cu Produced by 68 Zn( n , x ) Reaction Using nat C( d , n ) Neutrons ,” Journal of the Physical Society of Japan, vol. 83, no. 7, pp. 073201, 2014. View at Publisher · View at Google Scholar
  • Thomas Michael Martin, Vihar Bhakta, Abeer Al-Harbi, Michael Hackemack, Gabriel Tabacaru, Robert Tribble, Sriram Shankar, and Gamal Akabani, “Preliminary Production of 211At at the Texas A&M University Cyclotron Institute,” Health Physics, vol. 107, no. 1, pp. 1–9, 2014. View at Publisher · View at Google Scholar
  • Jamey P. Weichert, Paul A. Clark, Irawati K. Kandela, Abram M. Vaccaro, William Clarke, Marc A. Longino, Anatoly N. Pinchuk, Mohammed Farhoud, Kyle I. Swanson, John M. Floberg, Joseph Grudzinski, Benjamin Titz, Anne M. Traynor, Hong-En Chen, Lance T. Hall, Christopher J. Pazoles, Perry J. Pickhardt, and John S. Kuo, “Alkylphosphocholine Analogs for Broad-Spectrum Cancer Imaging and Therapy,” Science Translational Medicine, vol. 6, no. 240, 2014. View at Publisher · View at Google Scholar
  • Wei-Hsin Hsu, Si-Yen Liu, Ya-Jen Chang, Chih-Hsien Chang, Gann Ting, and Te-Wei Lee, “The PEGylated liposomal doxorubicin improves the delivery and therapeutic efficiency of 188Re-Liposome by modulating phagocytosis in C26 murine colon carcinoma tumor model,” Nuclear Medicine and Biology, 2014. View at Publisher · View at Google Scholar
  • Irene Tsiapa, George Loudos, Eirini A. Fragogeorgi, Penelope Bouziotis, Dimitrios Psimadas, Stavros Xanthopoulos, Maria Paravatou-Petsotas, Lazaros Palamaris, Alexandra D. Varvarigou, Dimitris Karnabatidis, and George C. Kagadis, “Evaluation of alpha(nu)beta(3)-Mediated Tumor Expression with a Tc-99m-Labeled Ornithine-Modified RGD Derivative During Glioblastoma Growth In Vivo,” Cancer Biotherapy and Radiopharmaceuticals, vol. 29, no. 10, pp. 444–450, 2014. View at Publisher · View at Google Scholar
  • Ondrej Sedlacek, Jan Kucka, Jana Mattova, Martin Parizek, Martin Studenovsky, Marie Zadinova, Pavia Pouckova, and Martin Hruby, “Multistage-targeted pH-responsive polymer conjugate of Auger electron emitter: Optimized design and in vivo activity,” European Journal of Pharmaceutical Sciences, vol. 63, pp. 216–225, 2014. View at Publisher · View at Google Scholar
  • F. Alam, M. Naim, M. Aziz, and N. Yadav, “Unique roles of nanotechnology in medicine and cancer,” Indian Journal Of Cancer, vol. 51, no. 4, pp. 506–U387, 2014. View at Publisher · View at Google Scholar
  • Boris I. Kharisov, Sergei S. Berdonosov, and Oxana V. Kharissova, “Radioactive nanoparticles and their main applications: Recent advances,” Recent Patents on Nanotechnology, vol. 8, no. 2, pp. 79–96, 2014. View at Publisher · View at Google Scholar
  • Yanchao Wang, Ruichao Liang, and Fang Fang, “Applications of Nanomaterials in Radiotherapy for Malignant Tumors,” Journal Of Nanoscience And Nanotechnology, vol. 15, no. 8, pp. 5487–5500, 2015. View at Publisher · View at Google Scholar
  • Masako Kawabata, Kazuyuki Hashimoto, Hideya Saeki, Nozomi Sato, Shoji Motoishi, Kosuke Takakura, Chikara Konno, and Yasuki Nagai, “Production and separation of Cu-64 and Cu-67 using 14 MeV neutrons,” Journal Of Radioanalytical And Nuclear Chemistry, vol. 303, no. 2, pp. 1205–1209, 2015. View at Publisher · View at Google Scholar
  • Wei Li, Zhongyun Liu, Chengxia Li, Ning Li, Lei Fang, Jin Chang, and Jian Tan, “Radionuclide therapy using 131I-labeled anti-epidermal growth factor receptor-targeted nanoparticles suppresses cancer cell growth caused by EGFR overexpression,” Journal of Cancer Research and Clinical Oncology, 2015. View at Publisher · View at Google Scholar
  • Aurore Rauscher, Mathieu Frindel, Holisoa Rajerison, Sébastien Gouard, Catherine Maurel, Jacques Barbet, Alain Faivre-Chauvet, and Marie Mougin-Degraef, “Improvement of the Targeting of Radiolabeled and Functionalized Liposomes with a Two-Step System Using a Bispecific Monoclonal Antibody (Anti-CEA × Anti-DTPA–In),” Frontiers in Medicine, vol. 2, 2015. View at Publisher · View at Google Scholar
  • Achraf Al Faraj, Basem Alotaibi, Abjal Pasha Shaik, Khaled Z. Shamma, Ibrahim Al Jammaz, and Jürgen Gerl, “Sodium-22-radiolabeled silica nanoparticles as new radiotracer for biomedical applications: In vivo positron emission tomography imaging, biodistribution, and biocompatibility,” International Journal of Nanomedicine, vol. 10, pp. 6293–6302, 2015. View at Publisher · View at Google Scholar
  • Lei Chen, Xiaoyan Zhong, Xuan Yi, Min Huang, Ping Ning, Teng Liu, Cuicui Ge, Zhifang Chai, Zhuang Liu, and Kai Yang, “Radionuclide I-131 labeled reduced graphene oxide for nuclear imaging guided combined radio- and photothermal therapy of cancer,” Biomaterials, vol. 66, pp. 21–28, 2015. View at Publisher · View at Google Scholar
  • D. Psimadas, T. Tsotakos, E. Fragogeorgi, and G. Loudos, “Nanomedicinal Approach of Getting Across the Brood-Brain Barrier with Nanomedicinal Nanoparticles,” Current Medicinal Chemistry, vol. 22, no. 37, pp. 4257–4270, 2015. View at Publisher · View at Google Scholar
  • Navideh Aghaei-Amirkhizi, Leila Moghaddam-Banaem, Sodeh Sadjadi, Mitra Athari-Allaf, and Fariba Johari-Daha, “Development of Dendrimer Encapsulated Radio-Ytterbium and Biodistributionin Tumor Bearing Mice,” IEEE Transactions on Nanobioscience, vol. 15, no. 6, pp. 549–554, 2016. View at Publisher · View at Google Scholar
  • B. Palazzo, B. Palazzo, S. Scialla, F. Scalera, N. Margiotta, and F. Gervaso, “Nanostructured Ceramics and Bioceramics for Bone Cancer Treatment,” Advanced Composite Materials, pp. 209–273, 2016. View at Publisher · View at Google Scholar
  • Wei Li, Yan-Hui Ji, Cheng-Xia Li, Zhong-Yun Liu, Ning Li, Lei Fang, Jin Chang, and Jian Tan, “Evaluation of therapeutic effectiveness of I-131-antiEGFR-BSA-PCL in a mouse model of colorectal cancer,” World Journal Of Gastroenterology, vol. 22, no. 14, pp. 3758–3768, 2016. View at Publisher · View at Google Scholar
  • R. Gabbasov, M. Polikarpov, V. Safronov, E. Sozontov, A. Yurenya, and V. Panchenko, “Monte Carlo simulation of dose distribution in water around 57Fe3O4 magnetite nanoparticle in the nuclear gamma resonance condition,” Hyperfine Interactions, vol. 237, no. 1, 2016. View at Publisher · View at Google Scholar
  • Neufeld, Bodis, Datta, Krishnan, Speiser, Kuster, and Hofmann, “Magnetic nanoparticle-induced hyperthermia with appropriate payloads: Paul Ehrlich's “magic (nano)bullet” for cancer theranostics?,” Cancer Treatment Reviews, vol. 50, pp. 217–227, 2016. View at Publisher · View at Google Scholar
  • Kritee Pant, Ondřej Sedláček, Robin A. Nadar, Martin Hrubý, and Holger Stephan, “Radiolabelled Polymeric Materials for Imaging and Treatment of Cancer: Quo Vadis?,” Advanced Healthcare Materials, vol. 6, no. 6, 2017. View at Publisher · View at Google Scholar
  • Liang-Cheng Chen, Ya-Jen Chang, Su-Jung Chen, Wan-Chi Lee, Chih-Hsien Chang, Te-Wei Lee, and Jui-Hung Shien, “ Imaging, biodistribution and efficacy evaluation of 188 Re-human serum albumin microspheres via intraarterial route in an orthotopic hepatoma model ,” International Journal of Radiation Biology, pp. 1–10, 2017. View at Publisher · View at Google Scholar
  • Wenpei Fan, Bryant Yung, Peng Huang, and Xiaoyuan Chen, “Nanotechnology for Multimodal Synergistic Cancer Therapy,” Chemical Reviews, 2017. View at Publisher · View at Google Scholar
  • Syed M. Qaim, “Nuclear data for production and medical application of radionuclides: Present status and future needs,” Nuclear Medicine and Biology, vol. 44, pp. 31–49, 2017. View at Publisher · View at Google Scholar
  • Muktika Tekade, Prashant Kesharwani, Rahul Maheshwari, Kamal Dua, Rakesh Kumar Tekade, Namrata Soni, Pallab Bhattacharya, and Philp M. Hansbro, “Recent advances in oncological submissions of dendrimer,” Current Pharmaceutical Design, vol. 23, no. 21, pp. 3084–3098, 2017. View at Publisher · View at Google Scholar
  • Carolina A. Ferreira, Shreya Goel, and Weibo Cai, “Exogenous Radionanomedicine: Inorganic Nanomaterials,” Radionanomedicine, pp. 13–47, 2018. View at Publisher · View at Google Scholar
  • Wei Li, Danyang Sun, Ning Li, Yiming Shen, Yiming Hu, and Jian Tan, “ Therapy of cervical cancer using 131 I-labeled nanoparticles ,” Journal of International Medical Research, pp. 030006051876178, 2018. View at Publisher · View at Google Scholar
  • Leila Farzin, Shahab Sheibani, Mohammad Esmaeil Moassesi, and Mojtaba Shamsipur, “An overview of nanoscale radionuclides and radiolabeled nanomaterials commonly used for nuclear molecular imaging and therapeutic functions,” Journal of Biomedical Materials Research Part A, 2018. View at Publisher · View at Google Scholar
  • Mine Silindir-Gunay, and A. Yekta Ozer, “Liposomes and micelles as nanocarriers for diagnostic and imaging purposes,” Design of Nanostructures for Theranostics Applications, pp. 305–340, 2018. View at Publisher · View at Google Scholar