953537.fig.003a
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Figure 3: In vivo actively nanotargeted radionuclides of  64Cu-DOTA-QD-RGD for dual-function PET and near-infrared fluorescence (NIR) imaging of U87MG tumor vasculature mice animal model. (a) PET images of 64Cu-labeled nanoparticles of DOTA-QD or DOTA-QD-RGD. Arrow heads indicate tumors. (b) Liver uptake of 64Cu-labeled nanoparticles of DOTA-QD or DOTA-QD-RGD. (c) U87MG tumor uptake of 64Cu-labeled nanoparticles of DOTA-QD or DOTA-QD-RGD. (d) Two-dimensional image of the 2 mice shown in (a) at 5 hr after injection (reprinted with permission from reference [37]). DOTA: 1,4,7,10-tetraazacyclodocecane- N, N , N , N - tetraacetic acid chelators for radionuclides labeling. QD: Quantum dots conjugated with NIR probe. RGD: Arginine-glycine-aspartic acid peptide for targeting tumor angiogenesis integrin 𝛼 v 𝛽 3 .