The Structure and Function of Serum Opacity Factor: A Unique Streptococcal Virulence Determinant That Targets High-Density Lipoproteins

Table 3

Distribution of SOF among M protein serotypes of S. pyogenes.

SOF-positive serotypes	2, 4, 8, 9, 11, 12, 13, 22, 25, 27, 28, 44, 48, 49, 58, 59, 60, 61, 62, 63, 66, 68, 73, 75, 76, 77, 78, 79, 81, 82, 84, 85, 87, 88, 89, 90, 92, 94, 96, 102, 103, 104, 106, 107, 109, 110, 112, 113, 114, 117, 118, 124
SOF-negative serotypes	1, 3, 5, 6, 14, 15*, 17, 18, 19, 23, 24, 26, 29, 30, 31, 32, 33, 34, 36, 37, 38, 39, 40, 41, 42, 43, 46, 47, 50, 51, 52, 53, 54, 55, 56, 57, 64, 65, 67, 69, 70, 71, 72, 74, 80, 83, 86, 91, 93, 95, 97, 98, 99, 100, 101, 105, 108, 111, 115, 116, 119, 120, 121, 122, 123

Data from Johnson et al. [77] and Beall et al. [21]. Streptococci are considered positive if SOF is expressed and/or the sof gene is present. Note that M types 7, 10, 16, 20, 21, 35, and 45 do not exist as these were subsequently found not to be group A streptococci.
^∗There are conflicting reports regarding whether M15 serotypes are negative or positive for SOF [77, 80].