Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer

Figure 1

Principles of CAR architecture. CARs consist of a binding moiety, an extracellular hinge and spacer element, a transmembrane region (TM), and the signaling endodomain. Commonly the binding moiety consists of scFv derived from a TAA-specific monoclonal antibody and the signaling domain(s) come(s) from activating and costimulatory immune receptors.