A Method for Individualizing the Prediction of Immunogenicity of Protein Vaccines and Biologic Therapeutics: Individualized T Cell Epitope Measure (iTEM)

Table 2

A summary of the results using the threshold model for iTEM’s association with immunogenicity listed in descending NPV for an iTEM threshold of 2.06.

		iTEM Threshold = 2.06			iTEM Threshold = 2.5
Study	𝑛	𝑃-value	PPV (%)	NPV (%)	𝑃-value	PPV (%)	NPV (%)
Human Tularemia	232	<.02	19	95	<.10	19	92
Tuberculosis	66	<.001	70	92	<.001	71	80
Smallpox	73	<.10	36	85	<.05	38	84
FPX	30	<.001	94	71	<.001	94	71
Mouse Tularemia	78	<.10	61	63	<.10	61	63
T1D	56	<.01	84	54	<.05	83	44