Mechanical and Electrophysiological Properties of the Sarcolemma of Muscle Fibers in Two Murine Models of Muscle Dystrophy: Col6a1 and Mdx
Figure 3
Topography (a, c, and e) and elasticity (b, d, and f) images obtained from a force map (64 64 force curves, max applied force = 1 nN) taken on a wild type (a,b), Col6a1 (c, d) and mdx (e, f) fibers. The rectangles in the middle indicate in a grey scale (increasing from black to white) the depth with a range of 210 nm in the topography images and the elasticity with a range of 1 kPa in the elasticity images. The white segments in the left lower corner corresponds to 1 m. g: Phase contrast image of a Col6a1 fiber in culture with the triangular AFM cantilever on top of it. The white cross indicates the position of the tip. The histogram in the right lower corner shows the average values of elasticity modulus Col6a1, mdx, and wild type fibers. significant difference compared to wild type, $ significant difference compared to Col6a1.
