Tropomodulin Capping of Actin Filaments in Striated Muscle Development and Physiology

Figure 1

Schematic of the molecular sequence and domain organization of Tmods and Lmods found in vertebrate striated muscle. Tmods contain an N-terminal TM-Cap domain and a C-terminal LRR-Cap domain, whose α-helices possess distinct combinations of TM-binding and actin-regulatory activities, as shown. The α-helices are numbered sequentially within each domain, and the NES and NLS of Tmods are highlighted. Lmods also contain a C-terminal extension with a polyproline region, two predicted α-helices, a basic region, and a WH2 domain.